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The principle of action of amoxicillin is to inhibit the synthesis of the bacterial cell wall, which leads to the rapid death of pathogenic microorganisms. At the same time, the threshold value of the minimum inhibitory concentration for various sensitive organisms varies. The prevalence of resistant strains of various pathogens also varies. It varies geographically and depending on the season. In this regard, it is desirable to focus on local information on resistance, especially in the treatment of severe infections, and to conduct additional tests.